ea0021oc3.2 | Young Endocrinologists prize session | SFEBES2009
Turban-Rajaonah Sophie
, Liu Xiaoxia
, Ramage Lynne
, Mullins John J
, Seckl Jonathan R
, Morton Nicholas M
Insulin-resistant diabetes is characterised by progressive pancreatic β-cell dysfunction. Elevated pancreatic islet activity of the intracellular glucocorticoid amplifying enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) was hypothesized to drive this process in genetically obese rodents. To determine the direct effects of elevated 11β-HSD1 on β-cell function in diabetes in vivo we created a transgenic model overexpressing 11β-HSD1...